Lecture notes and lecture slide shows can be downloaded from this page as PDF files (you will need the login and password given out in class). Files are generally made available at least a few days before the corresponding lecture. You will need Acrobat Reader 6.0 or higher to read these files.

Section 1: NUCLEOTIDES, REPLICATION, TRANSCRIPTION, and TRANSLATION

PowerPoint slides from Dr. Furneaux's introductory lecture

• Lecture 1: Introduction and outline of the course  (5.2 Mb)

PowerPoint slides from Dr. Eisenberg's lectures

• Lectures 2 and 3: Primary and secondary structure of DNA  (1.1 Mb)

• Lecture 4: DNA synthesis and repair  (1.3 Mb)

• Lecture 5: DNA repair II  (1.0 Mb)

• Lecture 6: DNA replication I: DNA replication enzymes  (0.9 Mb)

• Lectures 7 and 8: DNA replication II and III: Initiation and replication fork formation   (1.4 Mb)

PowerPoint slideshows from Dr. Furneaux's lectures

• Lecture 9: The central dogma  (3.8 Mb)

• Lecture 10: Transcription  (6.8 Mb) Link to the "Great Experiment Series"

• Lecture 11: Posttranscriptional events I  (6.7 Mb)

• Lecture 12: Posttranscriptional events II  (3.3 Mb)

• Lecture 13: Translation of mRNA: end of the dogma  (BIG FILE, 21.8 Mb)

• Lecture 14: Regulation by microRNAs  (7.9 Mb)

SECTION 2: AMINO ACIDS, PROTEINS, and ENZYMES

Lectures notes for Dr. King's lectures

• Lecture 15: Introduction to the amino acids  (0.9 Mb)   JBC classic paper   (1.1 Mb)

• Lecture 16: Protein ionization and buffers  (0.9 Mb)

• Lecture 17: Protein sequencing and purification  (1.8 Mb)

• Lecture 18: Techniques for protein mass determination  (2.9 Mb)

• Lecture 19: Protein secondary and tertiary structure  (3.0 Mb)

• Lecture 20: Protein structure determination  (2.9 Mb)

• Lecture 21: Structural genomics slides (5.5 Mb; download file then open in PowerPoint)  •  PDF version (5.3 Mb)
                  Liu and Rost paper (0.6 Mb)   •   Dihedral movie (Quicktime format, 1.0 Mb)  

Slides and papers from Dr. Hoch's lecture

PowerPoint slideshows from Dr. Furneaux's lectures

• Lecture 23: Enzymes   (7.6 Mb)   Sumner Nobel Lecture   (156 K)

• Lecture 24: Catalytic strategies  (7.5 Mb)   Krebs Nobel Lecture   (168 K)

• Lecture 25: Regulation of enzymes  (6.6 Mb)

• Lecture 26: Retro Biochemistry  (4.4 Mb)

• Furneaux Discussion/Tutorial Session on October 26: Satpute-Krisnan and Serio Nature paper  (0.3 Mb)

PowerPoint slides from Dr. Han's lecture

• Lecture 27: Proteomics  (2.6 Mb)

Section 3: Metabolism, membranes, and membrane transport

Lecture notes and slides from Dr. Eipper's lectures

• Lecture 28 - Biological Membranes I: Lecture Notes  (1.0 Mb)   Slides  (2.6 Mb)

• Lecture 29 - Biological Membranes II:Lecture Notes  (0.9 Mb)   Slides  (3.0 Mb)

• Lecture 30 - MembraneTransport I: Lecture Notes  (1.2 Mb)   Slides  (2.8 Mb)

• Lecture 31 - MembraneTransport II: Lecture Notes  (0.5 Mb)   Slides  (4.8 Mb)

• Lecture 32 - Biochemical Communications I: Lecture Notes  (1.1 Mb)   Slides  (2.8 Mb)

• Lecture 33 - Biochemical Communications II: Lecture Notes  (1.1 Mb)   Slides  (4.4 Mb)

Study guide for Dr. Setlow's lectures

• Reading material and study hints

• Diagrams of metabolic pathways  (4.1 Mb)

• Regulatory cascade for liver glycogen degradation  (0.6 Mb)

• Sample exam questions to be discussed at tutorial session on November 28

Lecture notes for Dr. King's lectures

• Lectures 39 and 40: Bioenergetics I and II: Lecture notes  (2.0 Mb)

• Lectures 393 and 40: Bioenergetics I and II: PowerPoint slides  (1.5 Mb)

• ATP synthase movie 1  (6.2 Mb)

• ATP synthase movie 2  (9.0 Mb)